Executive Team

The advisory group overseeing projects is made up of Prof Steve Wood, Prof Jon Cooper and Dr Alun Coker, individuals with a considerable experience protein structure determination and drug discovery. Selected publications illustrating this experience over the last ten years are provided below.

Austin C, Pettit SN, Magnolo SK, Sanvoisin J, Chen W-J, Wood SP, Freeman LD, Pengelly J. and Hughes DE. (2012) Fragment screening using capillary electrophoresis (CEfrag) for hit identification of Heat Shock Protein 90 ATPase inhibitors. J. Biomol. Screening 17:868-876.

Hussey, R., Coates, L., Gill, R., Erskine, P., Coker, S-F., Mitchell E., Cooper, J.,Wood, S., Broadbridge R., Clarke, I., Lambden, P., and Shoolingin-Jordan, P. (2011) A structural study of norovirus 3C protease specifity - binding of a designed active site-directed peptide inhibitor. Biochemistry 50: 240-249.

Kolstoe, S.E., Mangione, P.P., Bellotti, V., Taylor, G.W., Tennent, G.A., Deroo, S., Morrison, A.J., Cobb, A.J.A., Coyne, A., McCammon, M.G., Warner, T.D., Mitchell,J., Gill, R., Smith, M.D., Ley, S.V., Robinson, C.V., Wood S.P., and Pepys, M.B. (2010) Trapping of novel palindromic ligands within native transthyretin prevents amyloid formation. Proc Natl Acad Sci. USA 107(47):20483-20488

Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJA, Ley SV, Aquilina JA, Robinson CV, Sharif I, Gray GA, Sabin CA, Jenvey MC, Kolstoe SE, Thompson D and Wood SP. (2006) Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 440 :1217-1221.

Gill R, Mohammed F, Badyal R, Coates L, Erskine P, Thompson D, Cooper J, Gore M, Wood S. (2005) High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy Acta Crystallogr. D61:545-555.

Erskine PT, Coates L, Mall S, Gill RS, Wood SP, Myles DA, Cooper JB (2003). Atomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptides. Protein Sci 12:1741-1749.

Coates L, Erskine PT, Crump MP, Wood SP, Cooper JB (2002). Five atomic resolution structures of endothiapepsin inhibitor complexes: implications for the aspartic proteinase mechanism. J Mol Biol 318:1405-1415.

Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN (2002). Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417:254-259.